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Biosafety Virtual Library Resources
(VLR)
published: 07 Jun 2011
last updated: 10 Oct 2013
Consensus Document on Molecular Characterisation of Plants Derived from Modern Biotechnology (OECD 2010)
EN
- Inter-governmental organization (IGO)
2 rue André Pascal
Paris, Cedex 16,
75775,
Phone: +33 1 4524 8200,
Fax: +33 1 4524 8500,
Email:
Website: http://www.oecd.org/,
Organization:OECD Environment Directorate ()Inter-governmental organization (IGO), Environment, Health and Safety Division2, rue André-PascalParis Cedex 16,
75775,Phone:Fax: +33 1 44 30 61 80,Email: ehscont@oecd.org,Website: http://www.oecd.org/biotrack/,
Organisation for Economic Co-operation and Development (OECD), Paris
EN
2010-09
EN
© OECD 2010
EN
TABLE OF CONTENTS
ABOUT THE OECD
FOREWORD
PREAMBLE
SECTION I - BACKGROUND
A. Molecular Characterisation and Risk/Safety Assessment
B. National and International Experience
C. The Purpose of Molecular Characterisation
SECTION II - TRANSFORMATION METHODS
A. Introduction
B. Agrobacterium-mediated Transformation
C. Direct Transformation
D. Conclusions
SECTION III - INSERTED DNA, THE INSERTION SITE AND EXPRESSED MATERIAL
A. Inserted DNA and Insertion Site
-Integration and copy number
-Presence of plasmid backbone sequences
-Organisation of transforming DNA and sites of insertion
B. Expressed Material
-Transcription and translation
-Post-translational modification
C. Conclusions
SECTION IV - INHERITANCE AND GENETIC STABILITY
A. Introduction
B. Inheritance and Genetic Stability in Risk/Safety Assessment
-Patterns of inheritance .
-Factors of genetic stability
-Methods to determine the stability of a genetic modification
C. Conclusions
SECTION V - SUMMARY
SECTION VI - REFERENCES
EN
ABOUT THE OECD
FOREWORD
PREAMBLE
SECTION I - BACKGROUND
A. Molecular Characterisation and Risk/Safety Assessment
B. National and International Experience
C. The Purpose of Molecular Characterisation
SECTION II - TRANSFORMATION METHODS
A. Introduction
B. Agrobacterium-mediated Transformation
C. Direct Transformation
D. Conclusions
SECTION III - INSERTED DNA, THE INSERTION SITE AND EXPRESSED MATERIAL
A. Inserted DNA and Insertion Site
-Integration and copy number
-Presence of plasmid backbone sequences
-Organisation of transforming DNA and sites of insertion
B. Expressed Material
-Transcription and translation
-Post-translational modification
C. Conclusions
SECTION IV - INHERITANCE AND GENETIC STABILITY
A. Introduction
B. Inheritance and Genetic Stability in Risk/Safety Assessment
-Patterns of inheritance .
-Factors of genetic stability
-Methods to determine the stability of a genetic modification
C. Conclusions
SECTION V - SUMMARY
SECTION VI - REFERENCES
- GBF-T17. Strengthen biosafety and distribute benefits of biotechnology
No
No
No
Identifier (ISBN, ISSN, etc.)
JT03288491
Format
30 page PDF file
Keywords and any other relevant information
Series on Harmonisation of Regulatory Oversight in Biotechnology No. 51
and Series on the Safety of Novel Foods and Feeds No. 22
Citation: ENV/JM/MONO(2010)41
This Consensus Document was jointly developed by both the OECD Working Group on the Harmonisation of Regulatory Oversight in Biotechnology and the OECD Task Force for the Safety of Novel Foods and Feeds.
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